Abstarct: Objectives: The purpose of this study was to investigate the effects of an aerobic training course with the use of tomato juice on some inflammatory markers of overweight young girls. Method: This study was a clinical trial and included pre-test and post-test. The statistical sample of this study was overweight girls with an average age of 23.2 ± 2.1 years and BMI (27.25 ± 0.55 Kg / m2) who were randomly assigned into 4 groups of 12 : 1- Aerobic exercise 2- Tomato juice consumption 3- Aerobic exercise with Tomato juice and 4- Control group. Blood samples were collected before exercise and 48 hours after completion of exercise in fasting condition. The group performed aerobic exercises for 8 weeks with an intensity of 55-75% of maximum heart rate. In the first week with an intensity of 55% HRmax for 40 minutes and last week with an intensity of 75% HRmax for 50 minutes. Exercise in each session consisted of 10 minutes of warming and 30-35 minutes of main activity, which included various running exercises - aerobics-stationary exercises (aerobic training). Group 2 received 330 ml daily (1.5 times three times daily) with food intake of tomato juice. Group 3 also had aerobic training for 8 weeks, including (10 minutes warm-up, 30-35 minutes of main activity and 10 minutes of cooling), with 330 ml daily (1.5 times three times a day) to Together with the meals of tomato juice. A t-test was used to assess the difference between groups, ANOVA test was used to assess the difference between groups and Bonferron's post hoc test to identify the groups that made difference in ANOVA test. Results: The results showed that the serum level of IL-6 in group 3 (P = 0.015), serum CRP (CRP) level in group 3 (P = 0.017) ), Serum LDL levels in groups 1 (P = 0.11) and 3 (P = 0.002), serum TG levels in groups 1 (P = 0.016), 2 (P = 0.1010) and 3 ( P = 0.016), serum TC levels in groups 1 (P = 0.10) and 3 (P = 0.001) after intervention significantly decreased and serum HDL levels in groups 1 (P = 0.122) and 3 (P = 0.004) increased significantly. Also, a significant decrease in the percentage of body fat was observed in the group after intervention in group 3 (P = 0.40), and the BMI index was significantly decreased in group 3 (P = 0.022). In the intergranular test, there was a significant decrease in serum levels of IL-6, LDL, TC and body fat and a significant increase in serum HDL levels. Conclusion: According to the results of this study, it seems that the use of aerobic exercises along with the use of tomato juice is more suitable stimulant for counteracting inflammatory and free radicals in female patients.