Abstarct: Background and Aim: Since the non-alcoholic fatty liver disease (NAFLD )is a range of chronic liver disease in the world ,the purpose of the present study was the effect of six weeks high intensity intermittent exercise and taking supplements to improve NAFLD. Materials and Methods: This study was quasi-experimental research and the research community was including the girl’s students in Shahrood University of Technology. Among these, according to Morgan table, 450 individuals randomly selected for initial assessment baxsed on BMI and WHR and then130 individuals were identified as research sample. Among them, 70 people have been willing to cooperate in this study. After blood collection (measured in blood tests, including FBS, TG, CHOL, LDL, HDL, ALT, AST) and with early ultrasound 43 of them were identified with fatty liver. Then these were divided randomly into four groups; Which contains three groups of 10 and a group of 12 as follows: 1- intensity interval training (HIIT) + supplements of Cynarchol; 2- intensity interval training (HIIT); 3-Cynarchol supplement and 4 control group. Six weeks of training protocols defining for training groups. 1- intensity interval training (HIIT) and Cynarchol supplements have been done exercisethree times a week and each session for 1 to 1:15 minutes of high intensity intermittent exercise in the gym with average intensity of75 to 100% of maximum heart rate and consumes 1 unit of Cynarchol supplements after each meal . 2- Intensity interval training (HIIT): including three sessions per week, each session lasting 1 to 1:15 minutes of intense interval training for six weeks in a gym with an average of 75 to 100% of maximum heart rate.3-- Supplement of Cynarchol consumption of 1 unit Cynarchol after each meal supplements and 4. Control group with no intervention. It is noteworthy that regulation of a diet is very importance in studies on non-alcoholic fatty liver and for this reason subjects were asked to use of the food served in the kitchen of the University. Anthropometric and laboratory parameters for pre and post-test were measured after six weeks of training and supplementation intake and data using statistical methods withsignificant level P<0/05 tested. Results: The results showed that most differences between anthropometric variables including, WHR, BMI, body fat percentage, fat, muscle and body weight percentage of obesity and weight gain were significant changes. But indicators such as blood, SGOT, SGPT, TG, CHOL, HDL, LDL, FBS and body fat mass, no significant changes were observed during six weeks. Conclusion: The results showed that after six weeks of intense interval training and daily use of Cynarchol subject’s weight loss and body mass index and body and visceral fat decreases and overall anthropometric indices in subjects improved. There is not yet a cure for this disease and the need for further research in this area to achieve a useful strategy to prevent and strategies for treatment. Currently, the best method of treatment and prevention of this problem is changing of today's urban lifestyle.