Abstarct: Panavia F2.0 (Kuraray Medical Inc, Japan) dental resin cement with baxse of polymethylmextacrylate is mostly used cement applied in dentistry because of it physical and mechanical characteristics in comparison to other cements. Usage of hydroxyapatite in dentistry has been taken into consideration because it has some advantages such as high level of internal radiopacity equal to high level of hardness in natural teeth as well as improved frictional characteristics, such an ideal characteristics as well as crispness and friability of this bio ceramic made researchers use mixture of these materials with other items in order to eliminate its defect. This study tried to improve characteristics of dental cement by composition of resin cement with reinforcement phase of nanohydroxyapatite powder and to use active-biological characteristics of hydroxyapatite in mixing with cement, also this study analyzed the influenced of acid citric surface treatment on reinforcement powder. In this regard, three tests were done to measure compressive and micro-tensile strength and vikeers hardness. The sample of each test included four groups with different percent of reinforcement powder. The highest level of compressive strength was related to the group reinforced with 2 weight percent of coated nanohydroxyapatite powder done by coupling agent with increasing 136.7% strength in comparison to pure Panavia F2.0 dental cement, and the highest level of micro-tensile strength related to the group reinforced with 4 weight percent of coated nanohydroxyapatite powder done by coupling agent with increasing 41.3% strength in comparison to pure Panavia F2.0 dental cement. In all groups, fracture was brittle and porosities caused by confinement of air inside the cement created during mix of elements of cement was observed in samples of the test.