Abstarct: Iron oxide minerals are commonly found with some pyrite. The presence of pyrite causes the recovery of iron ores such as magnetite and hematite, Do not do it completely using magnetic separators. Therefore, in the steel industry, it is considered as a waste and disturbing mineral. Therefore, in this project, the ability of pyrite to float in the presence of xanthates was used to remove it from iron ore concentrate resulting from magnetic separation. The sulfur content in the iron concentrate factory product is too much for the consumption of pelletizing units. Therefore, it is necessary to reduce the amount of sulfur due to pyrite magnetic concentrate of Sangan iron ore, which is done by flotation method. For this purpose, the effect of various parameters such as the type and amount of collector consumption, type and amount of frother consumption, solid percentage and pH were investigated. Optimization of these parameters in flotation operations is necessary in order to achieve the permissible sulfur content in iron concentrate. By Design Expert software, the effect of operational factors was investigated and 23 experiments were designed. The results showed that by increasing the concentration of collector and frother, maximum sulfur recovery can be achieved. Obviously, this increase will increase to an optimal amount, and an excessive increase will reduce sulfur recovery. Decreasing the pH, increased sulfur recovery and improved particle flotation rate. At a collector concentration of 125 g / t, frother concentration of 105 g/t, solid percentage of 32% and pH=8, the production have sulfur content of 0.25% and a sulfur recovery of 68.9% can be achieved. Also, the collector distribution system was examined in three different modes at the beginning of the circuit: ruffer, cleaner, and scavenger as 100: 0: 0, 50:50:0, 50:30:20, which showed that when the system 50: 30: 20 is used, sulfur recovery is achieved in most cases.