Abstarct: The present study proposes an integrated system incorporating a gas turbine (GT), molten carbonate fuel cell (MCFC), a system of single-effect absorption refrigeration, and multi-effect desalination equipped with thermal vapor compression (MED-TVC). A comprehensive 4E analysis (energy, exergy, economic and environmental) has been done on the proposed system. For a better understanding of system performance, a parametric study was conducted to evaluate the impacts of the operating pressure and temperature of the MCFC, the steam-to-carbon ratio, the fuel utilization factor, current density, the desalination compression ratio, and the motive steam effect on the system. Molten carbonate fuel cell and gas turbine produce 96.2 and 50.32MW of power, respectively. The six-stage multi-effect thermal freshwater system has a production capacity of 126.9 kg/s of fresh water. The cooling and heating capacity of the system was obtained as 9.664 and 15.33 megawatts, respectively. And the current system has 114.1MW of output power. The results of the thermodynamic analysis showed that the efficiency of the fuel cell and the electrical and energy efficiency of the system are 49.96, 50.72 and 60.27%, respectively. The results of the environmental analysis on the system show that the carbon dioxide emission factor (EMI) is 389.3 kgCO2/MW and the carbon dioxide emission penalty cost is 926.8$/h. Also, the results of the exergy analysis showed that the exergy efficiency of the whole system is 50.89%, also the electrical exergy efficiency of the system and the exergy efficiency of the fuel cell system are 57.17% and 26.51%, respectively. In addition, the most exergy destruction occurs in the fuel cell, which is about 33% of the total exergy destruction. In the following, the system was analyzed from the economic aspect, the investment return period of 6.67 years was calculated for the system and the annual specific profit of 31 million dollars was observed for the proposed model. In addition, the investment return rate of 14.98 has been obtained for the multiple production system.