Abstarct: This study proposes energy, exergy, economic and environmental (4E) analyses of a novel integrated system incorporating solid oxide fuel cell (SOFC), gas turbine (GT), organic Rankine cycle (ORC) combined with steam ejector refrigeration (SER) system, and the multi-effect desalination (MED) unit with thermal vapor compression (TVC) to produce freshwater, power, heating, and cooling. A comprehensive parametric study was conducted on the proposed system and the main and important parameters include current density, fuel utilization factor, SOFC operating pressure and temperature, steam-to-carbon ratio, motive steam pressure of MED-TVC desalination system, compression ratio of desalination ejector, input heat to ORC-SER, ORC working medium mass flow rate and SER ejector entrainment ratio were analyzed. In the present work, the HYSYS and EES software packages are used to simulate and examine the analyses. The results show 53.255 MW of electricity generation, 148.3 kg/s of freshwater production, 4.758 MW of cooling, and 4.662 MW of heating. The total electrical efficiency, SOFC electrical efficiency, and total energy efficiency are 41.49%, 43.14%, and 48.83%, respectively. The EMI factor and the CO2 emission penalty cost were calculated as 475.9 kgCO2/MW and 528.7 $/h, respectively. The exergy analysis shows that the SOFC, the MED, and the heat recovery steam generator (HRSG) have the largest share of exergy destruction. In addition, an economic study of this system in Iran indicates a payback period of 5.7 years. Also, the levelized cost of freshwater and the levelized cost of electricity are equal to 0.007529 $/kg and 7.528 cent/kWh, respectively. Finally, according to simultaneous environmental and economic evaluations, the optimum value of the number of effects in the MED-TVC desalination unit can be 5.