Abstarct: One of these technologies that has been considered to convert solar energy into electrical energy is photovoltaic (PV) technology. The performance of a photovoltaic module is significantly affected by its surface temperature. Studies show that the efficiency of PV modules decreases by 0/3% for every 1°C increase in their surface temperature. Finding an efficient method to cool down PV modules is an important issue to improve their performance and increase their productivity. Examining the studies performed on PV module cooling systems, it can be concluded that high production capacity of liquid jet impingement cooling (JIC) system can be achieved. The electrical efficiency and performance of the PV/JIC system can be increased by designing the efficient geometry of the jet arrays, and by optimizing the parameters related to the nozzles, the uniform temperature distribution of the PV module can be achieved. In this research, the use of JIC system to reduce the surface temperature of a photovoltaic module and increase its production capacity has been investigated. First, pure water is used as the cooling liquid and the geometry of the JIC system is optimized using water, and then, SiC/water nanofluid is used for cooling. To obtain a uniform temperature distribution in the PV module, the main parameters such as nozzle diameter (dn = 1-2 mm), number and different arrangements for nozzles (N = 8-24), coolant flow rate (m) and nozzle distance (H=5-55 mm) from the back surface of the PV module is examined. The originality of this research can be found in two concepts. Initially, using pure water cooling, the temperature of 12 areas on the surface of a PV module was measured and the maximum and minimum temperatures as well as the variance of temperature data for the JIC cooling system were reported to check the effect of the proposed JIC system on uniform surface temperature distribution of PV module. The temperature uniformity index was defined and evaluated to illustrate the cooling efficiency of the proposed JIC system. Second, the response surface method (RSM) is used to determine the optimal operating conditions in the JIC system. Using JIC and water as the coolant, the average temperature of the module dropped from 64 ° C in the worst case to 43.3 ° C and the output power reached 6.58 W. The output power of the photovoltaic module increased with increasing water mass flow rate and number of nozzles. Conversely, by increasing the nozzle distance from the photovoltaic module and the nozzle diameter, the output power of the photovoltaic module decreased. Also, the predicted responses (temperature and output power) at the optimum point of 33.68 ° C and 8.610 W at a flow rate of 0.12 kg/s, number of nozzles=24, nozzle diameter=1.08 mm and the distance from the nozzle to the module are equal to 1.5 mm. After using water as a cooling liquid and obtaining the appropriate geometry and arrangement for the nozzles, the use of SiC/water nanofluid with different concentrations (φ = 0.25-1.1% wt) and investigating the effect of using the nozzle Single-hole and multi-hole nozzles on the electrical and thermal performance of PV modules have been performed. The results showed that the use of multi-hole nozzles has a more significant effect in reducing the temperature of the PV module than single-hole nozzles. On the other hand, it has been observed that with increasing the concentration of nanofluids, the temperature uniformity index is decreasing, which means a more uniform distribution of module surface temperature due to increasing the thermal conductivity of nanofluids and increasing heat transfer from the module surface to the impact jet. By increasing the nanofluid concentration from 0.25 to 1% by weight, it has led to a significant decrease in the surface temperature of the module. With increasing the concentration of nanofluid from 1 to 1.1 wt%, the rate of reduction in the module surface temperature decreased, which means that use of multi-hole nozzles and SiC nanofluid with a concentration of 1 wt% is a suitable choice and has the high ability for uniform distribution of module surface temperature. Therefore, this mode is recommended as the most efficient mode for cooling with fluid jet impingement cooling.