Abstarct: Using a topical drug delivery system with the ability to exert control over drug release rates can reduce treatment time and increase the rate of healing in skin diseases and chronic wounds. Traditional systems are generally passive because of their uncontrollability. In the present study a drug-carrying wound dressing with the aim of controlling drug delivery rate to the wound bed was studied. This system generally includes a drug delivery system, stimulation system and control system. The wound dressing is operated in such a way that by generating heat from a flexible microheater, the thermoresponsive drug carriers stimulate and so the drugs are released in a controlled manner to the target site. The irritable set consists of a thin hydrogels sheet, containing thermoresponsive NIPAM microparticles. Therefore, a flow focusing device was designed and fabricated by photolithography, and then the thermoresponsive microparticles were produced using it. Because of the similarity of triple distillation water with water-soluble drugs, the drug release was evaluated using it. So, first the microparticles were loaded with triple distillation water and then were surrounded in a hydrogel sheet. In order to control drug release rate, a gold and a gold-titanium microheater were separately fabricated on PDMS and PMMA substrates. In the characterization section, the microchannel performance was evaluated. The results showed that the droplets are produced uniformly. The 10% NIPAM flow was used as the intermittent phase and the liquid paraffin as a continuous phase. Increasing the ratio of the mass flow rate of discontinuous to continuous phase from 0.14 to 0.84 demonstrates increasing droplet diameter from 360 to 515 μm. The sensitivity of the microparticles to temperature was also examined by applying controlled temperature to the microparticles. The results showed that increasing the temperature from 18 °C to 32 °C reduces the droplet diameter up to 40%. Also examination of the performance of flexible microheaters showed that PMMA can be used as a suitable substrate. The results of electrical resistance measurements showed that the PDMS substrate is not suitable for gold sputtering. Also, the electrical resistance of gold and gold-titanium microheaters was measured about 220 and 150 ohms respectively.