Abstarct: Polymer-baxsed nanocomposites are among the most popular nanocomposites and have been investigated with the use of different polymers, reinforcements, and methods. In this research, a new approach is applied to produce MWCNTs / polyvinyl chloride (PVC) nanocomposite using a hot press mold and an automatic spray. The resulting nanocomposite, consisting of polymer and carbon nanotubes, is obtained using the laxyer-by-laxyer spray method. The therrmogravimetric and Raman spectroscopy analysis are used to examine of the weight percent and interaction of carbon nanotubes into the PVC matrix. Also, Design of Experiments (DOE) method by minitab 16 software is used for statistical control of the parameters influenced synthesis prosess. The results revealed that the optimal condition for the production of the nanocomposites is achieved with a weight percent of 5% and a mold surface temperature of 215°C. Then prepared samples from resultant laxyered nanocomposite are subjected to tensile test and Young’s modulus and final tension strength for optimal condition by 5% weight percent of carbon nanotubes are obtained 0.92±0.037GPa and 35±0.5MPa, respectively. The study is followed by performing low cycle fatigue tests in order to study the effect of adding two parameters of weight percentage and number of laxyers of carbon nanotubes to PVC. The results indicate by adding carbon nanotubes up to a weight percent of 5, the fatigue strength of the nanocomposites increases by approximately 80% (5000 numbers of cycles). Finally, the influence of various weight percent of carbon nanotubes on the Young’s modulus of nanocomposite is investigated via a new structural model in ABAQUS software. The results of the present structural model are compared with those from experimental method and show good agreement between this model and the spray method up to 20% weight percent of carbon nanotube.