Abstarct: Abstract This thesis examines the critical issue of identifying destructive earthquakes with the aim of reducing earthquake-induced damages, focusing specifically on the seismic behavior of special concrete frxames, with an emphasis on the effects of soil-structure interaction (SSI). Earthquakes pose a significant threat to buildings, and understanding how structures respond to seismic activities, especially considering the unpredictable nature of ground motions, is of utmost importance. This research also investigates the impact of SSI on frxames of varying heights 2, 6 and 10 stories, representing low-rise to high-rise buildings according to HAZUS guidelines—and these structures were modeled and analyzed under a wide range of soil conditions, from rock to soft soil, using the OpenSees platform. In this thesis, the modeling of SSI was performed using the beam-on-nonlinear-Winkler-foundation approach, combined with springs and dampers. The research process began with the selection of a comprehensive set of earthquake records, classified baxsed on shear wave velocity, for four distinct site types. Incremental dynamic analysis was conducted on these records to identify the most destructive earthquake scenarios, with the maximum inter-story drift considered as the failure criterion. Subsequently, through correlation analysis between earthquake intensity parameters and maximum inter-story drift, the parameters of Vmax/Amax, mean period (Tm) and F5 Power spectral density (PSD) were identified as those best indicating seismic damage potential. It was observed that the presence of SSI increases the natural period of structures, with this effect being more pronounced in taller buildings and softer soils. Additionally, the results of the incremental dynamic analysis curves indicated that with increasing building height and the inclusion of SSI, structures reach the HAZUS collapse state at lower peak ground acceleration levels, highlighting greater vulnerability in taller buildings and when SSI is considered, particularly in softer soils. Finally, this thesis presents two relationships baxsed on the three identified earthquake intensity parameters for determining destructive earthquakes in both scenarios, with and without considering SSI.