Abstarct: One of the challenges of water purification is the removal of organic pollutants with complex structures, such as dyes in wastewater, petroleum and phenolic compounds, and antibiotics that are difficult to decompose. In this study, the removal of organic pollutants phenol and tetracycline from wastewater with the help of mextal-organic frxamework catalyst baxsed on iron MIL88A-Fe in the heterogeneous Sonofenton process has been investigated. The mechanism of removing organic pollutants in this system was through the attack of active radicals OH● and O2●- produced during the process, on polluting molecules and breaking their structure into less dangerous substances such as carbon dioxide and water. The physical and chemical properties of the synthesized catalyst were determined using various SEM, EDS, FTIR, XRD, BET, UV-Vis, and zeta-potential analyses. To investigate the effect of effective factors on the removal efficiency of organic pollutants, various parameters such as the initial concentration of the pollutant, the amount of catalyst, the oxidizing amount of hydrogen peroxide, the initial pH of the solution, the contact time and the power of the ultrasonic waves were studied. The results of the experiments showed that the efficiency of phenol removal under optimal conditions of initial phenol concentration of 10 mg/l, pH = 7.5, the amount of hydrogen peroxide 50 microliters, the amount of catalyst 5 mg, the power of ultrasonic waves 512 watts and contact time 60 minutes, is equal to It was obtained with 97%. Also, the efficiency of tetracycline removal in the optimal conditions of initial concentration of tetracycline 30 mg/l, amount of hydrogen peroxide 20 microliters, amount of catalyst 50 mg, pH = 11, power of ultrasonic waves 640 watts and contact time 60 minutes, was equal to 95%. Examining pseudo zero, first and second order kinetic models of the reactions showed that the removal of the organic pollutant phenol in the heterogeneous Sonofenton process follows the second order kinetics and the organic pollutant tetracycline follows the first order kinetics.