Abstarct: River pollution is one of the critical environmental issues that may have direct and indirect effects on the health of humans, animals, and aquatic plants. The aim of this study is to assess water quality using IRWQI, NSFWQI, and Wilcox indices and compare them with global standards and zoning of the Kashkan River watershed using ArcGIS software. In this study, four sampling stations were selected along the river. Water quality parameters, including qualitative, toxic, cationic, and anionic elements, were measured along the river over a one-year period from autumn 1401 to summer 1402 using standard laboratory methods. Water pollution increased downstream due to agricultural runoff, industrial units, and urban and rural wastewater. According to the IRWQISC index, stations S1 and S2 were categorized as medium quality, while stations S3 and S4 were relatively poor quality. baxsed on the IRWQIST index, stations S1, S2, S3, and S4 were classified as very good quality. According to the NSFWQI index, all stations were categorized as having medium quality and lacked necessary standards for drinking purposes. According to the Wilcox index, river water is suitable for agricultural use. The results indicate that before consumption for drinking purposes, physical and microbial treatment should be applied. The presence of urban and rural wastewater and agricultural runoff in the Kashkan River basin is the most significant reason for the decline in water quality. In this regard, environmental management, baxsed on environmental monitoring and detection and measurement of environmental pollution, is essential for decision-making in this area.