Abstarct: Many national investments are spent on the maintenance of asphalt pavements every year. Rutting and cracking are two reasons for damaging to asphalt pavements. Among these two failure mechanisms, the cracks due to fatigue are found a lot in asphalt pavements. The use of new polymeric materials such as Geo-synthetics can enhance the life of pavements and prevent forming and spreading cracks. Also, nanomaterials have the potential for improving the performance of binder and asphalt pavement. Therefore, this experimental study evaluates the fatigue life of asphalt mixtures reinforced with Geo-grid or Geo-textile and with or without tack coat modified with Nano-silica. To this end, a four-point bending beam test was implemented under semi-sinusoidal load with a frequency of 10 Hz and without rest in a controlled strain mode including three strain levels of 400, 550 and 700 micro-strain at a temperature of 20±8℃. The results showed that the fatigue life increases in each of the samples containing the tack coat modified with Nano-silica as well as the Geo-grid and Geo-textile reinforcement. According to the results, the simultaneous application of Geo-grid or Geo-textile and tack coat modified with Nano-silica improved the fatigue life significantly. The maximum improvement on the fatigue life of pavement was 135% at the strain level of 700 micro-strain regarding the sample reinforced with Geo-textile and tack coat modified with Nano-silica, and the minimum improvement on the fatigue life of pavement was 19% at the strain level of 400 micro-strain regarding the sample reinforced with Geo-textile and tack coat modified with Nano-silica. In addition, by increasing the amount of constant strain from 400 to 700, the amount of cyclic load decreased but the rate of improvement of fatigue life increased.