Abstarct: Lignin, a phenolic polymer in the secondary plant cell wall, cross-lixnks with other matrix polysaccharides and cellulose microfibrils. It appears as a nuisance in wall-related industries such as pulp and paper and biofuel. Accordingly, many attempts made towards lignin reduction or improvement of its enzymatic hydrolysis. However, any tampering with lignin biosynthetic genes within the pathway had detrimental effects on plant growth and development, or on plant’s resilience before environmental stresses. Therefore, finding other co-expressed genes within the neighboring pathways would be a valuable task for engineering purposes towards subtle reduction of lignin content, with no major effect on plant stature and stress-tolerance level. In this study, a bioinformatic approach was taken into consideration to identify such genes through analysis of co-expressed genes with pivotal lignin biosynthetic genes: Phenylalanine ammonia lyase (PAL), cinnamate 4-hydroxylase or NADPH ;cytochrome p450 oxidoreductase (C4H) and P-coumarate 3-hydroxylase (C3H). The study was carried out in two model plants representative of grass family, Brachypodium distachyon, with minor lignin content and Glycine max as an oilseed dicot plant with greater amounts of lignin. PlaNet and Phytozome for B. distachyon and Phytozome for G. max were used to predict the co-expressed networks. Pathway Enrichment was carried out in phytozome, functions were assigned in Uniprot and KEGG and co-regulation analysis was performed in PlantPAN 2.0. The genes were classified into groups including but not limited to uncharacterized, response to stress genes, secondary wall biosynthetic genes, other genes involved in lignin biosynthesis and phenylpropanoid pathways, transcxription factors, RNA binding proteins, amino acid biosynthetic genes, nitrate transporter proteins, Endoglucanases, and L-ascorbate oxidase. The co-expressed gene networks were confirmed via promoter analysis and further regulatory networks were established through the identification of corresponding transcxription factors.