Abstarct: Salisination of agricultural lands is one of the most important factors in reducing yield and production of crops, especially in dry and semi-arid regions. Sesame is one of the important oil and vegetable seeds of these areas. Therefore, it seems necessary to find a suitable solution to reduce the damage to this plant. Recently, the supply of chemical fertilizers in the form of nanoparticles has been considered. In this regard, in three experimental parts, greenhouses and fields, the effect of seeding and seed priming with sodium nitroprusside and calcium on some of the agronomic and physiological characteristics of sesame were investigated under salt stress conditions. In vitro, the effect of seed primer with sodium nitroprusside (without penicillary, distilled water, 50, 100, 150 and 200 μm) and salinity stress (0, 50 and 100 mM / L) were investigated in order to determine the appropriate concentration of sodium nitroprusside in two The other part was examined. In the potted and field fields, the effect of sodium nitroprusside (control, pre-treatment of 150 μM, 50 μM and foliar application with seed primer), calcium soluble (control, calcium carbonate in the usual form and nano concentration of 4,000) And salinity stress (irrigation with non-saturated water and saline water) were investigated. In the laboratory section, the agronomic and morphological traits of sesame were measured in seed primer treatment with sodium nitroprusside with a concentration of 150 μM from other levels and this treatment was selected as seed primer for both pot experimental and field experiment. In the potting section, salt stress significantly decreased the agronomic and morphological traits, yield and yield components, chlorophyll content and calcium and oil content. Also, salinity stress increased about 5 times in catalase activity, also increased the activity of superoxide dismutase 9 times and ascorbate peroxide increased 10 times more than control. Sodium nitroprusside application reduced the effect of salinity stress on measured parameters. Seed primers and spraying with sodium nitroprusside and their application together increased agronomic and morphological traits, yield and yield components, antioxidant activity, chlorophyll, proline and calcium and oil content. The results of discriminative analysis indicated that the calcium carbonate application had a small effect on agronomic and morphological traits, yield and yield, activity of antioxidant enzymes and qualitative traits and sodium, calcium and proline, but the effect of different treatments on calcium carbonate foliar application on chlorophyll a, chlorophyll b, Chlorophyll a/b and chlorophyll were completely evident and caused differentiation of different treatments of carbonate calcium foliar application with control treatment. A similar process, such as a pot experiment, was seen in a field experiment. Salinity stress reduced the amount of agronomic and morphological traits, yield and yield, and calcium content, but sodium nitroprusside and calcium carbonate application increased these traits and improved the reduction of salinity stress. In addition, salinity stress, sodium nitroprusside, and calcium carbonate foliar application increased the activity of antioxidant enzymes, proline and protein levels, and reduced levels of malondialdehyde and oil. Finally, in the research area, foliar application along with seed primer with sodium nitroprusside, as well as foliar application with calcium nanocarbonate can be described as the best treatment combination.