Abstarct: During 2014– 2015 in a faunistic survey of chlorophid and tephritid flies in the central region of Khorasan Razavi province, a total of nine species belonging six genera of Chlorophidae are collected and identified, also Mohammadzade Namin`s personal collection is studied. One species is new record from Iran (there was in Mohammadzade Namin`s personal collection) and six species are new records from Khorasan Razavi province which are marked by two and one asterisks, respectively, also 12 species belonging nine genera of Tephritidae are collected and identified. Among them Valera ariana Mohamadzade, Memari & Hakimitabar, 2016 is described, five species which are marked by one asterisk are new records from Khorasan Razavi province. Flies species are listed as follows: Family Chloropidae Subfamily Oscinellinae 1–Aphanotrigonum Duda, 1932 Aphanotrigonum cinctellum Zetterstedt, 1848* 2– Oscinella Becker, 1909 Oscinella pusilla (Meigen, 1830)* Subfamily Chloropinae 3–Thaumatomyia Zenker, 1833 Thaumatomyia sulcifrons (Becker, 1907)* Thaumatomyia notate (Meigen, 1830) Thaumatomyia glabra (Meigen, 1830* 4– Meromyza Meigen, 1830 Meromyza nigriventris Macquart, 1835* 5– Lasiosina Becker, 1910 Lasiosina herpini Guérin–Méneville, 1843 Lasiosina paralittoralis Dely–Draskovits, 1981* 6– Platycephala Fallén, 1820 Platycephala rugosa (Nartshuk, 1964) ** Family Tephritidae Subfamily Tephritinae Tribe Tephritini 1– Tephritis Latreille, 1804 Tephritis postica (Loew, 1844) Tephritis pallescens Hering, 1961* 2– Acanthiophilus Becker, 1908 Acanthiophilus helianthi (Rossi, 1794) 3– Goniurellia Hendel, 1927 Goniurellia longicuada Freidberg, 1980* 4– Trupanea Schrank, 1795 Trupanea amoena (Frauenfeld, 1857) Trupanea stellata (Fuesslin, 1775) 5– Tephritomyia Hendel, 1927 Tephritomyia despoliata (Hering, 1956)* Tribe Terelliini 6– Terellia Robineau–Desvoidy, 1830 Terellia serratulae (Linnaeus, 1758) Tribe Myopitini 7–Urophora Robineau–Desvoidy, 1830 Urophora sp. near dirlbeki Mohamadzade, 2015 Urophora spatiosa (Becker, 1913)* Trib Xyphosiini 8–Valera Mohamadzade, 2016 Valera ariana Mohamadzade, Memari & Hakimitabar, 2016 Subfamily Trypetinae Tribe Trypetini 9– Euleia Walker, 1835 Euleia heraclei (Linnaeus, 1758)*