Abstarct: Lead (Pb) in environment poses a major threat to plant growth and can be absorbed through the leaves and roots of plants. In such conditions plant nutrition can be effective in the tolerance of plant to Pb stress. So in this study the effects of calcium and zinc foliar were evaluated on agronomic and physiological traits in safflower under lead stress. The experiment was laid out in a factorial baxsed on randomized complete block design with three replications at the greenhouse and farm of Agricultural Research Center of Kerman. The first factor was the treatment of lead. In the pot experiment, the lead treatments were control, soil application of lead, foliar application of lead and combined soil and foliar application of lead and in the farm experiment lead foliar in applied three concentrations (0, 0.5 and 1 mM as acetate lead). The second factor was zinc foliar in three concentrations (0, 10, 20 mM as sulphate zinc) and the third factor was calcium foliar in two levels (0 and 10 mM chloride calcium) were applied in both pot and farm experiments. Foliar was done in the pot and field experiments 65 and 130 day after planting, respectively. 15 days after was sampled and measured traits. In field and pot experiments, zinc foliar spraying had the positive impact on the reduction of lead accumulation in different parts of the plant, maintaining chlorophyll, increasing soluble carbohydrate and anthocyanins, reducing lipid peroxidation of membranes, yield and growth improvement and oil seed content and increased the activity of antioxidant enzymes under lead stress. In pot experiment, zinc (20 mM) foliar in combined Pb application was increased lead accumulation in leaf, seed and root 65, 50 and 39 percentage compared to zero zinc level respectively. In pot experiment, zinc (20 mM) foliar in combined Pb application was decreased lead accumulation in leaf, seed and root 65, 50 and 39 percentage compared to zero zinc level respectively. In field experiment, zinc application (20 mM) in lead stress (1mM) was decreased lead accumulation in leaf and seed 57 and 50 percentage compared to zero zinc level respectively. In pot experiment, calcium application was increased biological yield, oil yield, calcium concentration in different parts of the plant, increasing the root volume, leaf area, plant dry weight and the activity of ascorbate peroxidase, reducing the amount of lead and malondialdehyde in leaves in lead stress. For example, in the combined application of lead, biological yield, oil yield, leaf area increased 11, 45, 20% compared to zero calcium level. In farm experiment, plant nutrition with calcium increased calcium content in leaves and seeds, head number per plant, leaf area index and relative water content in leaf and chlorophyll concentration under lead stress (1mM) and the least of lead concentration in both leaves and seeds was observed in calcium application. Pb accumulation in leaf and seed decreased 40 and 45 percentage respectively. Combined Ca and Zn application had the most alleviating effect on seed number per head, biological yield, leaf and stem dry weight, biological yield, reducing lead content in seed and the concentration of malondialdehyde in combined application of lead at pot experiment and lead accumulation in seed, chlorophyll concentration at farm experiment under lead stress with a concentration of 1 mM. In the range of lead stress treatments in pot and field experiments, the use of 20 mM concentration of zinc sulfate and 10 mM concentration of calcium chloride as foliar were significant. So it seems that application of calcium and zinc caused against the toxicity of lead by improvement in physiological and growth processes leading to the tolerance of the plant to lead stress.