Abstarct: Second mextabolites isolated from salvia spices mostly are terpenoids and flavonoids, which are bioactive compounds with high healthy effects. But most of this materials after extraction from plant, are chemically unstable and when consumed has shown lower healthy effects. This food-drug (Nutraceuticals) compounds have act with other materials in food materials or due to stability and low solubility and their unpleasant flavor have limited. For eliminate this problems, we can use carrier systems to encapsulate and improve functional properties of food-drug materials. So, in this study nanoemulsion was prepared by using high intensity ultrasound method. Tween 80 and spin 80 surfactants, salvia Sahandica essential oil was used as oily phase and water as nanoemulsion compound separator. Also, for nanoliposome preparation, the thin laxyer hydration method was used, and phosphatidylcholine as a molar ratio of 1 to 1 with saliva essential oil, was used. For hydration, the ratio of 4 to 6 glycerol and water were used. In this study, the antioxidant properties of essential oils of s. Sahandica and nanocarriers were measured using DPPH radical. The antimicrobial properties of nano-carriers and salvia sahandica essential oil was done by two methods, microdilution and macrodilution. The results indicate that we achieve optimum particle size and particle size distribution for nano-emulsion formulations, respectively was 0.38 ± .0.01 and 89.45 ± 0.41 and 01.0 1.53 ± 82.87 nm and optimal formulation Nanoliposome was respectively 0.42±0.01 and 82.87±1.53. The encapsulation efficiency for nanoemulsion and nanoliposome was of 69% and 84% respectively. Antioxidant effect of essential oil and nanocarriers showed significant differences, so that the nanoemulsion containing the oil and free oil representated the highest and the lowest antioxidant properties, respectively. The results of microbial experiments on micro-dilution and macro dilution method showed that, the impact of the oil in both free and encapsulated in lipid carriers state against Gram-positive bacteria (staphylococcus aureus, Bacillus cereus) were higher than on Gram-negative bacteria (E.coli and Moraxella catarrhalis). Antimicrobial activity of essential oils and nanocarriers showed significant differences, so that the nanoemulsion containing essential oil and free essential oil had the highest and lowest antimicrobial activity, respectively. In general, antimicrobial and antioxidant activities of nanoemulsion were higher than nanoliposome. As a result nanoemulsion can be usefull carrier for increasing of antimicrobial and antioxidant activities of s. sahandica essential oil.