Abstarct: The present research was conducted in order to assess the water and soil contamination by heavy mextals and potentially toxic elements due to Ay ghalasi mineralization and abandoned lead-zinc mine. The study area is located 30km southeast of Takab, northwest of Uromia-Dokhtar volcanic zone, Azarbayjan, Iran. Samples included 23 samples from the soil in the site, 4 samples from the tailing soil, 2 samples from the tailing rock, 14 water samples from streams (mine drainage and the Posht-dareh stream) and springs, as well as 18 sediment samples from the bottom of the main stream covering the area from upstream toward the downstream (catchment outlet). The physico-chemical parameters and the concentrations of heavy mextals in the samples (using ICP-OES techniques) were determined. baxsed on the concentrations of elements, type of mineralization, and environmental priorities some elements namely Pb, Zn, As, Cd, Ni, Hg, Sb, and Cu were selected for further investigations. Some softwares were employed to summarize, illustrate, and analyze the collected data including. Arc GIS 9.3, SPSS 17, ،PHREEQC 2.15, and Aq.QA. The geological studies showed that marl, sandy marl, and calcareous marl are widely spread in the region while the mineralization occurred in oligomiocene sandy marl unit along the main fault of the area (northeast-southwest), northwest of Ayghalasi Village. The geochemical studies on tailing soils showed that the concentrations of Pb, Zn, As, and Cu was high and the modified contamination degree was infinite. A comparison between tailing and site soils showed that both contained a uniform, low concentrations of Cd which indicated that the mineralization had no influence on the concentration of Cd. With the same analogy, mineralization had no effect on the concentrations of Ni and Hg. In contrary, concentration of Sb showed to be high in all samples while the mineralization increased Sb in soil samples collected from the nearby mine. In the majority of samples from situ soils, the concentrations of Pb, Zn, As, Ni, and Sb were higher than world soil average and Pb, Zn, and As concentrations had increased in nearby mining zone. The results of tests on drainages (AMD), surface water resources, and drinking water in the region showed that the concentrations of Zn and Cd in the mine drainage were higher than standards for wastewater effluent while they tend to reduce with the distance to the abandoned mining zone. The drinking water resources (springs) in the area was contaminated with Sb. The water type in the area near the mineralization zone, Ayghalasi, and Khankandi was calcic sulphate which is an indication of the effects of mineralization and anthropogenic activities. According to Schuler's diagram, the water resources in the region were in the good to acceptable level. The calculation of saturation index showed that all water samples were under-saturated with regard to anhydrite, halite, and gypsum while they were over saturated by calcite, dolomite, and aragonite. Calculating the mextallic load of the water samples showed that the drainage samples were in the acidic range with high mextallic load, the surface water near the ore deposit were in neutral range with high mextallic load while the rest of samples were in neutral range and low mextallic load. The highest concentrations of Pb, Zn, Cu, and As occurred in sediments beneath the mine drains, downstream of the tailing near the main tunnel. Calculation of the mean enrichment factor showed that the sediments in the region were highly enriched with regards to lead and zinc and infinite enrichment with As. According to the mean contamination factor, the sediment in the region are highly contaminated with lead, zinc, and arsenic.