Abstarct: Abstract Mayamey barite-lead-copper deposit is located in the northernmost part of the Central Iranian zone, 50 km east of Shahrood city and 15 km south of Mayamey town. The rock units of the region include conglomerate, shale and limestone interlaxyers of Jurassic age, Early Cretaceous basal red conglomerate, as well as limestone and shales of the Late Cretaceous. The main host rocks for mineralization is the Cretaceous limestone. Mineralization has occurred in the form of lens masive, breccia, vein-veinlets, replacement and open-space fillings. According to microscopic studies, the major ore minerals include barite, chalcopyrite, galena, pyrite and malachite, goethite and hematite. Alterations associated with ores are dolomitization in the host crabonates and silicic-sericitic within the basment granites. According to the involved fluid inclusion studies, the samples contain dominantely two-phase (L+V) inclusions. The homogenisation temperature of fluids in the analyzed samples are between 120 and 161 centigrade degrees, and their salinity varies between 1.3 and 6.7 NaCl eq. %. Geochemical studies show that the elements probably originated from the underlying shales. According to the studies carried out in terms of type of the host rock, ore controls, fluid temperature and salinity, structure and textures of ores, lack of connection of the mineralization with the intrusive masses, ore mineralogy, carbonate alteration and geochemical studies, this mineralization shows the most similarities with the Mississippi Valley type (MVT) deposits.