Abstarct: The proximity of agricultural lands to mine tailings is the most important source of soil contamination of the Irankuh mining district. Regarding the negative impacts of potentially toxic elements on natural ecosystems, it is very important to suggest efficient approaches for remediation of soil and mine waste. In this study, the representative soil and waste samples were collected from the study area and the total concentration and speciation of Pb, Zn, Cd and As were determined using standard methods. The results of sequential extraction analysis indicate that in the agricultural soil and tailing samples, Pb, Zn and Cd were mainly associated with carbonate and oxide phases; whereas As in agricultural soil was mainly present in oxide and residual fraction, and in tailing sample it was dominantly present as exchangeable and residual phase. On the basis of mextal speciation results in the studied samples, the electrokinetic remediation on the representative soil sample was conducted using three different materials, e.g. Sodium hydroxide, Acetic acid, and Na2EDTA. On the tailing and waste rock samples, the electrokinetic remediation was conducted using Hydroxyl ammonium chloride and Sulfuric acid, respectively. The obtained results indicate that the electrokinetic remediation using the Na2EDTA chelating agent was the most successful approach for soil remediation and 30.58% Zn, 23.8% Cd , 18.53% Pb and 4.05% As were removed from the soil sample. The higher removal efficiency of Na2EDTA for soil sample is probably due to the presence of high concentration of the studied elements in oxide and carbonate fractions and the high chelating ability of Zn and Pb with Na2EDTA. In the soil sample, the electrokinetic remediation using acetic acid and sodium hydroxide was not efficient, perhaps due to the mineralogy of the soil as well as the speciation of the studied elements. The obtained results indicate that the efficiency of electrokinetic method for remediation of the tailing and waste rock samples was very low, probably due to the high presence of elements in non-bioavailable fractions as well as the high concentration of numerous pollutants in the waste materials.