Abstarct: The advancement of wastewater treatment techniques stands as a significant environmental concern. Among the array of methods employed, advanced oxidation processes (AOPs), particularly photocatalytic degradation, have garnered considerable attention for being non-destructive and sustainable approaches. This study undertakes the synthesis of a mextal-organic frxamework MIL-101(Cr) via the solvothermal method, leveraging its distinctive characteristics such as a low band gap and high specific surface area. Subsequently, the synthesis and analysis of MIL-101(Cr)/Ag3PO4/AgBr photocatalyst with a low band gap and the ability for visible light activation were conducted, characterized through Fourier Transform Infrared Spectroscopy (FTIR), Field Emission Scanning Electron Microscope (FESEM), Energy-Dispersive X-ray Spectroscopy (EDX), X-ray Diffraction (XRD), and Diffuse Reflectance Spectroscopy (DRS). The photocatalytic performance was assessed baxsed on the concurrent degradation of Orange G dye (anionic dye) and Rhodamine B dye (cationic dye). The Extended Ratio Subtraction Method (EXRSM) was employed to resolve the spectral overlap created by Orange-G at the maximum absorption wavelength of Rhodamine B. The optimization of the dual-color degradation was conducted using the central composite Face-Centerd test design method (CCF) with the response surface method (RSM) technique. Through the desirability chart, the optimal levels of effective parameters were determined as follows: irradiation time of 70 minutes, catalyst amount of 39.6 mg, orange color concentration of 0.5 mg/liter, and rhodamine B color concentration of 0.4 mg/liter. Under these optimal conditions, the maximum degradation efficiency for Orange G and Rhodamine B was achieved at 94.29% and 99.45%, respectively