Abstarct: Absstract In this study, fluoride removal from aqueous solutions was investigated by mextal-organic frxamework MIL-101(Al)-NH2. The physicochemical and surface characteristics of this organic-mextallic frxamework were determined using FT-IR, XRD, FESEM and EDX techniques. The effects of pH of the solution, contact time, amount of adsorbent, initial concentration of fluoride solution and temperature on the removal efficiency and absorption capacity of the adsorbent were investigated. The obtained laboratory data were analyzed using four Langmuir, Freundlich, Dubin-Radushkij and Temkin isotherm models. The maximum adsorption capacity was obtained by the Langmuir adsorption isotherm of 119.05 mg/g at a temperature of 298 K, pH = 5.9, The initial concentration of fluoride is 5 mg/l and the adsorbent amount was 30 mg. baxsed on the results, the highest correlation coefficient equal to R2=0.997 was obtained for Freundlich adsorption isotherm, which can be said that the adsorption process follows this isotherm. According to the kinetic data obtained from the investigation of three pseudo-first-order, pseudo-second-order and particle diffusion models, it was concluded that the pseudo-second-order model is a better descxription of the laboratory data. The results obtained for thermodynamic parameters such as ∆H◦, ∆S◦, ∆G◦ showed that the absorption process of the endothermic surface is spontaneous and accompanied by an increase in disorder. Adsorbent recovery with ethanol was better than other applied materials. According to the results of mextal-organic frxamework MIL-101(Al)-NH2 can be used as a suitable adsorbent with high absorption capacity for the treatment of water sources.