Abstarct: In this research, some supported polysilsesquioxanes with different functional groups have been prepared for using in catalytic reactions. Poly-chloropropylmethyl-silsesquioxanes have been prepared by different ratio of methyl-tri-methoxy-silane and chloropropyle-tri-ethoxy-silane. The best ratio has been chosen upon different characterization methods and it was used for substitution of its chlorine atoms by different amines. These amine functionalized polymers were used to support MoO2(acac)2 complex and applied to the epoxidation of different alkenes. The selected polymer was also used to support a copper phthalocyanine complex and it was used to catalyse oxidation of benzyl alcohol reaction. Then Poly-mercaptopropylmethyl-silsesquioxanes have been prepared by different ratio of methyl-tri-methoxy-silane and mercaptopropyle-tri-methoxy-silane. The best ratio has been chosen upon different characterization methods and it was used for grafting Silver iodide. This functionalized polymer has been used in photo-catalytic degradation of Rhodamine B dye in aqueous solution under visible light irradiation. Finally, due to the comparison of the performance of amine and thiol groups along with the methyl group, polymeric some samples were prepared by different ratio of methyl-tri-methoxy-silane, mercaptopropyle-tri-methoxy-silane and aminopropyle-tri-ethoxy-silane. These polymers have been used to support silver nano-particles and after characterization, they were used in reduction of 4-nitrophenol as catalyst. In addition, the antifungal activities of these mextallic silver supported polymers were investigated against macrophomina and fuzarium oxysporum fungi.