Abstarct: Heteropolyacids, due to the high thermal stability, are suitable inorganic catalysts for the various oxidation and epoxidation reactions. In this study, heteropolyacides of H4[PW12O40], H4[SiW12O40], H5[PMo10V2O40], H5[PW10V2O40] and H4[PMo11VO40] were prepared and suported on a polyaniline substrate . The structure of these compounds were investigated by analyzes of FT-IR, XRD, UV-Vis, FE-SEM and EDX. Also, ICP analysis was performed to determine the amount of mextal in the catalysts. The GC was also used to investigate the progress of catalytic reactions. Then, their catalytic function was investigated in the reaction of epoxidation alkenes in heterogeneous condition and it was optimized for different parameters. The antibacterial properties of the compounds were also evaluated. Studies showed that in this reaction, the time and amount of catalysts have a significant effect on the progression of the reaction. Antibacterial studies of these compounds were performed on a number of pathogenic species such as fusarium, macrophomina fungus, botrytis fungi and pseudomonas syrinae.