Abstarct: In this experimental research work have studied morphological, structural, optical, thermoelectrical, electrical and also, photoconductivity properties of nanostructured thin laxyers of pure copper oxide (CuO) grown by spray pyrolysis method. For physical characterization of samples we have used filed emission scanning electron microscope (FESEM), X-ray Diffraction (XRD), UV-Vis spectroscopy, current-voltage measurement and Seebeck effect experiment. The studied samples have been prepared using copper acetate mono hydrate precursor. In this research we have investigated various parameters including: the substrate temperatures (315, 375 and 440°C), precursor concentration (0.05, 0.10 and 0.15 M), volume of precursor (40, 50 and 70 ml) and also the substrate material. At the end of each section the photoconductivity properties of the laxyers irradiated with visible light has been studied. FESEM images indicate the formation of CuO Nano particles and ribbons and flower- like particles. X-ray diffraction spectra indicate the formation of samples in polycrystalline monoclinic structure and mainly grown along preferential (002) and (111). Photoconductivity properties of the samples show that, the surface morphology, crystal quality and crystalline size affect on the light sensitivity.