Abstarct: Abstract: Sleep apnea is a form of respiratory disorders and a common health problem. Studies report that, Regular physical activity including aerobic exercise is non-pharmacological strategies for treatment of sleep disorders and apnea. The aim of this study is comparing acute effects of aerobic activity with hypoxi periodic on levels of nitric oxide, blood pressure and indicators of pulmonary function in patients with obstructive sleep apnea. Methods: 11 male volunteers with obstructive sleep apnea (_24.54+-10.24 old) performed an aerobic exercise consisted in 40 minutes by running on treadmill with intensity of 70%heart rate reserve. During intermittent hypoxia session, 5 minutes hypoxic air (11% oxygen) and 5 minutes normoxic air (room air) were inhaled intermittently at sitting position for an hour in separate days. lung function (FVC, FEV1, TV, PEF, FEV1), blood pressure and nitric oxide ,befor and after that the practice time was measured. .the normality of the distribution of test data Shapiro_wilk and analysis of variance with repeated measurement was used to analysis and paired t-test was used to compare the results between groups differences. To investigate the relationship between the desired changes in some variables, Pearson correlation were used. The analysis performed by Spss22 and surface operations considered less than 5%. Results: nitric oxide levels increase and Systolic blood pressure levels reduced significantly after aerobic exercise and intermittent hypoxia .However nitric oxide, Systolic, bloodpressure at 40,50and60 minutes ، decreased significantly only in intermittent aerobic exercise (P≤0.05). Reduction in systolic blood pressure at 50 minute wassignificantly correlated with the PEF post 30 and 60 minute (P≤0.05). Conclusion: In general it can be concluded that an aerobic exercise protocol of the hypoxia periodic activity, nitric oxide and blood pressure systolic and diastolic in patients with obstructive sleep apnea improves.Communication systolic blood pressure in 50 minutes with indicator PEF half an hour after exercise represents improved distention lung after workout. Application seems to be 40 minute of aerobic exercise at 70% heart rate reserve, a major factor in response to nitric oxide, blood pressure and dilates lung after exercise. This method has less limitations in comparison with regular exercise at the same time and expected to fulfill the aim, the regular practice for a wider range of people, including the sick, disabled and older applicant.