Abstarct: In diabetic patients, levels of inflammatory factors is high and maybe reduction of these factors Lead to reduction the mortality from CVD in these patients. Lifestyle changes and the use of exercise as a way to improve cardiovascular health have been posed And on the other hand because of the side effects of chemical drugs to control inflammation, the use of alternative treatments or supplements are considered By researchers; Therefore, we following answer this question whether the eight-week aerobic exercise with nettle supplementation are affected on hs-CRP inactive middle-aged women with type II diabetes? for this purpose, 42 inactive middle-aged women with diabetes were randomly divided into four groups: aerobic exercise with nettle supplements, exercise with placebo, taking Nettle and control. 8-week aerobic exercise program consisted of 3 sessions per week of running on a treadmill for 55-30 minutes with intensity 65-45% heart rate reserve, which first week starting with low intensity and at eight weeks to reach maximum intensity. Dosage of Nettle and Placebo was 6 cc in 3 times after eating meals, Blood samples were taken One day before the first and 48 h after the last training session. For comparison of data used t-test and one way ANOVA and significant level (P< 0.05) was considered. After eight weeks, the control group (P< 0.894), supplement (P< 0.685) and exercise with placebo (P< 0.556) there was no significant change in the levels of hs-CRP, only the aerobic exercise group with nettle consumption decreased hs-CRP (P< 0.029) which was statistically significant. It seems to accompany a medicinal plant with regular aerobic exercise can reduce inflammation in diabetic patients.