Abstarct: Methods of reducing obesity have been of interest to researchers in recent studies. Physical activity in the long-term causes angiogenesis and prevents inflammation, hence the present study aimed to compare of the effect of one session a continues and high intensity intermittent aerobic exercise on VEGF and TNF –α levels of soleus muscle tissues in obese male rats. To carry out this study, 45 adult male eight weeks Wistar rats were fed a high-fat diet for eight weeks. After the end of eight-week diet, when 27 rats had the appropriate weight (320±10gr), they randomly were divided into three groups: control, the continuous aerobic activity and the high intensity intermittent activity. After exhaustive tests, to determine the maximum of oxygen consumption, groups of periodic training protocol includes warm-up, five sets of high intensity (100% VO2max), which were separated with periods of low intensity (30% VO2max) and did cool down. Intensity in the continuous training group was equivalent to 65% VO2max and run duration baxsed on the displacement of high intensity interval training group were calculated. The descxription and soleus muscle tissue were collected immediately after animals’ activity. In order to analyze the data, one-way ANOVA test were used and significance level was set at p≤0/05 The results showed that one session of a high intensity intermittent exercise compared to the control and continuous group significantly decreased in the levels of VEGF and VEGF levels in continues group compared to the control group was not significant. Also, TNF-α level in all three groups showed no significant decrease. It seems, doing an intermittent exhaustive exercise can reduce VEGF and continuous exercise causes no changes in VEGF in soleus muscle, which may be it could be justified due to the higher training intensity of the intermittent against continues training. Also, according to the lack of significant changes in TNF-α and lack of inflammation, can benefit in weight loss programs and improve the health of obese people.