Abstarct: Introduction: Isometric contractions and external muscle activities are usually used by athletes with various goals and have been discussed in modern scientific literature, but the combination of these exercises together, under the name of quasi-isometric external exercises (EQI), have remained relatively unknown. These exercises emphasize holding the load at a certain angle until failure and performing the outward phase of the movement with the greatest resistance and the slowest possible speed. Examining the morphological and functional effects of EQI exercises in the research literature is very limited and there is a need for long-term research in the field of these variables. The aim of the study was to investigate the response following a bout of quasi-isometric external resistance activity, with and without blood flow restriction, on the levels of growth hormone, IGF-1, and lactate concentration. Methodology: The current research was a semi-experimental type with a pre-test and post-test design. The participants in this research were 27 inactive women with the age range of 25 to 40 years who had not had regular resistance training in the last six months and were randomly divided into three groups: quasi-isometric extrinsic activity (EQI), resistance activity with blood flow restriction (BFR) and The quasi-isometric eccentric activity was divided by the blood flow restriction (EQI+BFR). Body mass index (BMI) of subjects in EQI group (27.93 ± 2.094), in BFR group (26.90 ± 1.866) and in EQI + BFR group equal to (26.90 ± 1.158) was After anthropometric measurements, including height, weight, and body mass index, and estimation of a maximum repetition by the Brezisky formula, the maximum arterial occlusion pressure of the participants was evaluated in order to personalize the target flow restriction pressure by Doppler ultrasound technique. Then, on 2 separate days, the participants performed upper and lower body activities in 3 sets until exhaustion with 120 seconds rest between sets. Venous blood samples of the subjects were collected in two stages before and immediately after performing the activity. Then three blood factors growth hormone, insulin-like growth factor and lactate were measured. Result: Intergroup examination using the analysis of variance test showed that there was no significant difference between the three groups in the variables IGF-1 and GH and lactate (05/0 = p). Also, a bout of EQI residual activity with and without blood flow restriction had a significant effect on the change in blood GH concentration between before and after 3 sets of activity to residual upper body. However this significant increase in IGF-1 was not observed. However, examination of lactate levels showed that after performing resistance activities, lactate levels increased significantly in all three intervention models (p ≥ 0.05). Conclusion: The increase in lactate as an indicator of mextabolic stress indicates the success of these methods in applying pressure to the body's anaerobic system. This study also supports the usefulness and effectiveness of EQI and BFR resistance training on increasing growth hormone secretion, which can be considered as a response to hypertrophy baxsed on the present findings. It can also be acknowledged that the use of the proposed models can be used interchangeably to comply with the principle of diversity.