Abstarct: Diabetes is one of the most important health problems in all societies. Synergistic effect of sports activities and drug, especially supplements, it is considered to be one of the best methods of improving the condition of people with diabetes. The purpose of this study was the effect of aerobic and synbiotic exercise on arterial stiffness, C-reactive protein and malondialdehyde in postmenopausal women with type 2 diabetes. In this semi-experimental study, 39 eligible people were selected to enter the study and baxsed on fasting blood sugar, they were randomly divided into three groups: aerobic exercise + placebo (13 people), aerobic exercise + synbiotic supplement (13 people) and synbiotic supplement (13 people) were divided. The program of aerobic exercises included 10 minutes of warm-up, 25 minutes of activity with an intensity of 40-45% of the maximum heart rate, which was added every two weeks by 5 minutes to the duration and 5% to the intensity of the activity, and 5 minutes of cooling down. Placebo and aerobic + synbiotic for 12 weeks and three sessions per week. Aerobic + synbiotic and synbiotic groups also consumed one capsule with a count of 1 x 109 CFU) one hour after having lunch. At the end of the study, biochemical indicators were measured and evaluated. Statistical analysis was done using SPSS software, using one-way analysis of variance and Bonferroni's post hoc test. The findings of the present study in the intra-group study showed that the ABI increased significantly in the group of aerobic exercise + placebo (p=0.039) and aerobic exercise + synbiotic supplement (p=0.028). Also, ankle cardiovascular index (CAVI) in aerobic exercise + placebo (p=0.002) and aerobic exercise + synbiotic supplement (p=0.022), C-reactive protein in all 3 groups aerobic exercise + placebo (p=0.001), aerobic exercise + synbiotic supplement (p=0.0001) and supplement Synbiotic (p=0.002), malondialdehyde in all 3 groups aerobic exercise + placebo (p=0.015), aerobic exercise + synbiotic supplement (p=0.023) and supplement Synbiotic (p=0.047) and serum levels of LDL in the group of aerobic training + synbiotic supplement (p=0.005) were significantly reduced. Also, serum levels of HDL increased in all 3 groups of aerobic exercise + placebo (p=0.019), aerobic exercise + synbiotic supplement (p=0.046), and synbiotic supplement (p=0.003), and the maximum oxygen consumption index (VO2max) in 2 groups of aerobic exercise + placebo (p=0.0001) and aerobic exercise + synbiotic supplement (p=0.003) Increased. Also, serum levels of triglyceride, cholesterol, fasting glucose, insulin, insulin resistance index, BMI and body fat percentage did not show any significant difference in any of the groups. In the inter-group comparison, the VO2max index showed a significant increase (p=0.002) and no significant difference was observed in the rest of the indices. From the obtained results, it is possible to recommend the use of aerobic exercise program along with synbiotic supplement to type 2 diabetic women.