Abstarct: Background and Objectives: Aging signals may mediate the unique role of visceral fats in the negative impact on the body of the inflammatory component of obesity. Exercise reduces markers of aging phenotype and age-related secretory phenotype in visceral adipose tissue while reducing physical damage. Therefore, the aim of the present study was to compare the differences between high-intensity and low-intensity interval training on the exxpression of aging-dependent genes in visceral adipose tissue of young mice. Materials and Methods: In the present study, 15 male Wistar rats ate the high-fat diet available for nine weeks. After reaching the obesity stage, rats were randomly divided into three groups of 5 including control group, high-intensity interval group and low-intensity interval group. Subsequently, the high-fat diet of the animals was changed to the standard diet. The rats trained five sessions per week for 8 weeks. Each high-intensity interval training (HIT) session consisted of one hour (60 minutes) of exercise, during which the rats first warmed up for 5 to 10 minutes with an intensity of 50 to 60% VO2max, and then 5 8-minute intervals with an intensity of 85 to 90%. VO2max followed by two-minute intervals of 50 to 60% VO2max followed by cooling for 50 to 60% VO2max for 5 minutes. The low-intensity interval training group (LIT) after 5 to 10 minutes of warm-up with an intensity of 50 to 60% VO2max, to perform 5 8-minute intervals with an intensity of 55 to 60% VO2max, with two-minute intervals with an intensity of 45 to 50% VO2max They were separated, polished, and finally cooled for 5 minutes at 50 to 60% VO2max. At the end of the training period, all the studied animals were killed and operated on using the appropriate method of facilitation. exxpression levels of P53, P16, and IL-6 genes were measured by Real-time RT-PCR. Data were analyzed by SPSS software using the Shapiro-Wilk test (to check the normality of data) and one-way analysis of variance (to test hypotheses). Results: There was a significant difference between the exxpression of P53 and IL-6 genes compared to the reference gene in the three groups of subjects (p <0.05). On the other hand, there was no significant difference between the exxpression of P16 gene compared to the reference gene in any of the groups (p <0.05). Conclusion: In general, the results of the present study showed that 8 weeks of high-intensity and low-intensity periodic training can significantly reduce the exxpression of P53 and IL-6 genes compared to the reference gene, compared with the control group. These changes were also significantly different between high and low intensity training groups and HIIT exercises were more effective. The effect of exercise on the exxpression of P16 gene was not statistically significant in any of the groups, despite a noticeable decrease.