Abstarct: Abstract Objectives: The purpose of this study was to investigate the safety of resistance training and its effect on clinical signs and quality of life of type 2 diabetic patients with peripheral neuropathy. Method: This study was a clinical trial and included pre-test and post-test. The statistical sample of this study was men with type 2 diabetes with peripheral neuropathy with an average age (41.5±5.65 years) and body mass index (29.03 ±55.92 Kg / m2), baxsed on grade Patients' neuropathy (MDNS score) was divided into 2 resistance training groups (20 people) and control (17 people). Group 1 performed resistance exercises for 12 weeks with intensity of 50-85% for 1RM and for 30 to 45 minutes. The exercises in a progressive resistance program with an initial intensity of 50-60% in the first four weeks of the first routine and increased to 75-85% of 1RM in the last weeks. A combination of eight moves was performed for 8 to 12 repetitions in 1-3 sets. 12 weeks of training were performed in combination of upper and lower trunk in each session. The exercises were three sessions per week and two designed training sessions were run each session in such a way that the first program (Roeing sitting and Leg press and front arm of the cushion stand and Smith's legs) at the first session and the program The second (the chest and back of the thigh and the extension of the arm and abdomen of the kranch) in the second session and in the third session was re-programmed first and so until the 12th week, so that each week each program It was done twice in circulation. Before the exercises and 48 hours after completion of the exercises, blood samples were collected in fasting state and the questionnaires were completed by subjects. The control group did not have any activity during the study period. Finally, dependent t test was used to assess in-group difference and independent T test to assess the difference between groups at a significant level of P <0.05. Results: The results showed that in the experimental group, peripheral neuropathic score (P = 0.001), serum fasting glucose (P = 0.0001) and hemoglobin A1C (P = 0.0001) decreased after intervention Significant and quality of sleep (P = 0.005), quality of life (P = 0.0001) and fatigue (P = 0.0001) were significantly improved. There was also a significant decrease in BMI index (P = 0.001) and waist circumference (P = 0.0001) in the experimental group. In the intergranular test, there was a significant decrease in the score of peripheral neuropathy and serum fasting glucose and a significant increase in sleep quality and quality of life (P <0.05). Conclusion: According to the results of this study, the use of resistance training is a suitable stimulus for coping with the score associated with peripheral diabetic neuropathy and improving the indicators related to the quality of life of these patients and can be used as a safe treatment protocol in Diabetic patients with neuropathy.