Abstarct: Background and Purpose: Non-alcoholic fatty liver disease is a wide range of chronic liver disease worldwide that prevalence of this disease increased with urban life, inactivity and the obesity. The purpose of this study was to compare the effects of aerobic exercise and vitamin E on liver of non-alcoholics fatty liver disease in high school students of Shahrood. Materials and Methods: for this study BMI and WHR of 2028 boys of high school students were measured. BMI of more than 107 numbers were above 30 and their WHR was 0/9 t 44 of these subjects participated in this study. To evaluate the risk of having fatty liver administrated ultrasound and have been done blood tests for measuring liver enzymes (ALT and AST). By a single radiologist performed ultrasound in the presence of fatty liver grading view (GRADING) was performed according to standard international definitions. Then for measuring their blood tests (AST / ALT / HDL / LDL / CHOL / TG / FBS) were sent to the laboratory. Average age if subjects was 15/7 years, and all of them have fatty liver and then randomly divided into 4 groups : 1; Aerobic training with diet, 2; Vitamin E and diet, 3; Aerobic exercise - Vitamin E and diet, 4; Diet group. Protocol of intervention for each group was defined for eight weeks. - 1 - Aerobic training group, aerobic exercise training 3 times a week, each session lasting 30 to 45 minutes running on the treadmill with intensity 60 to 75% of maximum heart rate, and diet equal with 1,800 -2,400 BMR calories per day, self-reported. 2- Vitamin E and diet: 400 mg daily oral intake of vitamin E and diet as group 1. 3- aerobic exercise and vitamin E with diet group, aerobic exercise like the first group and vitamin E intake at a dose of 400 mg daily.4- Diet group, with BMR between 1800 to 2400 calories per day in self-reported. Laboratory and anthropometric indices were measured before and after eight weeks of intervention. The data using statistical methods, paired t-test and ANOVA, for comparison within groups at a significance level of P< 0/05 tested. Results: The results of this research showed in the first group and within group comparison, variable of weight, BMI, WHR, TG, CHOL and liver fat were significant and in the variables of FBS, LDL, HDL, ALT and AST statistically were not significant. In variables of second group, WHR, TG, CHOL, ALT and liver fat accumulation was a significant reduction and decrease in weight factors, BMI, FBS, LDL, HDL, and AST statistically were not significant. And in the third group the differences between pre-test and post-test variables, weight, BMI, WHR, ALT and liver fat accumulation was significant and differences between variables of FBS, TG, CHOL, LDL, HDL, and AST were not significant(P< 0/05). In the fourth group differences in variables and reduction of weight, BMI, CHOL, LDL and lipid accumulation in the liver observed and differences and reduction in variables of FBS, WHR, TG, HDL, ALT and AST were not seen. In comparison between-group were not significant differences between the groups showed except in reduction of the CHOL and HDL variables. Conclusion: This study showed that after 8 weeks of weight loss intervention improvement in liver enzyme levels, blood lipid levels, BMI, WHR, and liver fat accumulation occurs in all groups. But to achieve a therapeutic agents and strategies and assess how best to influence , non-alcoholics fatty liver disease need of further research and ways to prevent obesity at an early age and the intervention of urban life .