Abstarct: Abstract Purpose: The purpose of this research is to investigate and compare 4 weeks of IMT and interval training on arterial blood oxygen saturation (SpO2) and ventilatory response during exercise in non-athletes. Method: This research plan is pre-test and post-test. The statistical sample of this research project is 30 people who were selected from the students of Shahrood University of Technology aged 20-40 and randomly divided into 3 groups of submaximal endurance interval training, IMT training and sham group training. Before starting the exercise protocol, subjects were given a sheet to fill in to evaluate them according to the study entry criteria. If their information does not conflict with the study entry criteria, they will be prevented from entering the research project. Then, each of them filled out the consent form (a sample of which is in the attachment) to enter this study with their own personal desire. Interval group: performed submaximal endurance exercises in interval for 4 weeks. In the first two weeks, they ran with a maximum intensity of 60 and at least 40% of the reserve heart rate with a training frequency of 3 days a week, and in the second two weeks with a maximum intensity of 70 and at least 50% of the reserve heart rate and a training frequency of 4 days a week. IMT group: performed breathing exercises in the presence of the researcher for 4 weeks. In the first two weeks, they performed this exercise protocol with an intensity of 50% of PImax and 30 respiratory efforts for 4 days a week. In the second two weeks, the training intensity increased from 50 to 60 maximum inspiratory pressure and the number of training sessions increased from 4 to 5 sessions. Sham group: same as the IMT group, but with an intensity between 10 and 15% of PImax, they tried to breathe. Statistics: Correlated t-test was used to examine intra-group changes and Covariance (ANCOVA) with post hoc Bonferroni test with 95% confidence was used to examine inter-group changes. (P=0.05). Results: The results show that the mean SpO2 was not significantly different between the 3 groups (P>0.05). Also, intra-group changes show that the difference between pre-test and post-test in SpO2 index characteristics is not significant (P>0.05). In the interval group, the mean of minute ventilation, the amount of received frequency and also the amount of fraction compared to the results of the pre-test decrease significantly (P<0.05). In other training groups, there were no intra-group differences in the changes of ventilation indices during training compared to the pre-test report (P>0.05). Conclusion: By performing 4 weeks of interval and breathing exercises, no significant difference was found between the three interval, IMT and sham training groups in the parameters of mean arterial oxygen saturation (SpO2) and ventilation factors during exercise.