Abstarct: Background and Aims: Diabetes and its complications are one of the main reasons for the decrease in quality of life and various diseases, including atrtrial stiffness. Although it has been shown that patients with type 2 diabetes can benefit from the mextabolic, cardiovascular, and other health benefits of exercise, very little research has been done to investigate the effect of exercise training on arterial stiffness and possible pathways. Therefore, the aim of this study was to investigate the effect of combined exercise on Adropine levels and arterial stiffness in depressed type 2 diabetic women. Materials and Methods: The statistical population of the present study was depressed type 2 diabetic women referred to Shahroud Diabetes Association, of which 34 were randomly divided into two groups: 1) Training group (N=17, with a mean age 60.6±6.3yrs, and body mass index 30.2±1.3kg/m2, And fasting blood sugar 161.4±15 mg/dl). 2)Control group (N=17, with a mean age 60.6±6.4yrs, and body mass index 29.9±1.2kg/m2, And fasting blood sugar 169.1±16.mg/dl).The exercises training consisted of 3 sessions per week for 12 weeks and each session consisted of 20 minutes of aerobic running training on a treadmill with an intensity of 50-75% of the reserve heart rate and also 40 minutes of resistance training with an intensity of 50-75% 1RM. Blood samples were taken 48h before training and 48h after training on the fasting state. ELISA method was used to measure Adropin. Arterial stiffness and blood pressure were also tested using the VaSera-200 system. Data were analyzed at the significant level using Kolmogorov-Smirnov test, dependent t-test and analysis of covariance(p<0.05). Results: Data analysis showed that Adropine levels in the experimental group were significantly increased compared to the pre-test and control groups P<0.05. Also, body composition factors, body mass index (BMI) and waist /pelvic ratio (WHR) The pretest had a significant decreaseP<0.05, but these changes were not significant compared to the control group P>0.05. Also, all 3 arterial stiffness indices (cardio-ankle vascular index (CAVI), toe-brachial index (TBI), ankle brachial index (ABI) in the experimental group compared to the control group had a significant decrease, but only compared to the pretest. There was a significant decrease in the index ABI and also systolic and diastolic blood pressure were significantly reduced in the training group compared to the pre-test.but compared to the control group, there was only a significant decrease in diastolic blood pressure P<0.05. Conclusion: In general, it seems that combined exercise training can reduce blood pressure and especially arterial stiffness in women with depressive type 2 diabetes, and this by affecting the effective factors vascular compliance as well as factors related to diabetes and It is realized with the focus on Adropine.