Abstarct: Objective: The purpose of this study was to investigate the effect of 8 weeks aerobic exercise with cinnamon intake on migraine headache indices. Methodology: This study was a clinical trial and included pre-test and post-test. The statistical sample of this study was women suffering from migraine headache with average age of 31.69 ± 6.53 and BMI of 23.3 ± 3.2. They were randomly divided into four groups of 14 subjects: 1. Exercise Group (n = 14), 2. Cinnamon Group (n = 13), 3. Exercise + Cinnamon Group (n = 13), and 4. Control Group (n = 14). Groups 2 and 3 took a capsule of cinnamon containing 500 mg every morning for 8 weeks. The MIDAS questionnaire was collected before exercise and after 48 hours of exercises and cinnamon intake. The exercise program for patients in the exercise group was performed increasingly in the form of aerobic exercise for eight weeks, and every week included three sessions with given duration and severity (50% to 75% HR). First week was 30 minutes exercise including 5 minutes warm up (walking, soft running, tension on the body, and calisthenics), 20 minutes aerobic exercise (including running, aerobic movements, and various ball games with moderate intensity), and 5 minutes cool down. The second and third weeks included 35 and 45 minutes exercise, respectively, and the eighth week included 50 minutes scheduled exercise. The dependent t-test was used to assess the within-group difference, the covariance analysis test was used to assess the between-group difference, and the Bonferroni post hoc test was used for the detection of the groups that caused differences in covariance analysis at the significance level of p≤0.05. Results: The findings showed that in within-group comparison, headache frequency was significantly decreased in Group 1 (p = 0.043) and Group 3 (p = 0.11) after intervention, while the headache duration was also significantly decreased in Group 1 (P = 0.012), Group 2 (p = 0.009), and Group 3 (p = 0.009) after intervention. In the between-group comparison, Group 3 showed a significant decrease in headache duration index compared to the control group (P = 0.026). The severity of headache decreased significantly in Group 1 (p = 0.004) and Group 3 (p = 0.001) after intervention. In the between-group comparison, Group 3 showed a significant decrease in headache intensity index compared to the control group (P = 0.006). In the within-group comparison, BMI showed a significant decrease in group 3 (P = 0.023). In addition, in the within-group comparison, a significant decrease in the maximum oxygen consumption index after intervention was observed in Group 3 (P = 0.046). In the between-group comparison, Group 3 (P = 0.026) showed a significant decrease in the level of maximum oxygen consumption compared to the control group. Conclusion: According to the results of this study, aerobic exercise simultaneously with cinnamon intake seems to be a good stimulus for reducing the headache duration, headache severity, and headache frequency in women suffered from migraine headache.