Abstarct: The aim of present study is to evaluate the effect of one session exhausting aerobic activity on some immune system’s factors in active male students. For this purpose 12-active male students, with the average 25.33±5.87 of age, 68.94±6.29 kg of weight, 178.60±6.06 cm of height, 11.87±7.21 of body fat percent and 58.08±10.80 ml/kg/m of maximum volume of oxygen uptake were studied. After Bruce protocol achievement in each session the subjects were immersed in a cold water (17°C) pool, warm water (32°C) pool or inactively rested without immersion. Before and after Bruce test performing and 20-minuts after immersing was ended, blood sample collection was done in order to evaluate the cellular immune system factors (white blood cells (WBC), neutrophils, lymphocytes and monocytes numbers) and serum immunoglobulins A by Nephelometry method and specific kit. Variance analysis test with repeated measures and LSD Post Hoc test in SPSS21 software with the significance level of 0.05 were used. Findings: exhausting aerobic Bruce test caused a significant increase in IgA, lymphocytes and neutrophils however this amount were back to its baxseline level after warm and cold water immersion and inactive rest. Conclusion: regarding this research results it could be admitted that an exhausting aerobic activity may cause an increased activity of immune system factors through the significant increasement of serum levels of IgA and posttest blood index changes, while these would come back to normal state after immersion in warm or cold water or inactive rest.