Abstarct: Introduction: Recently many disorders and diseases are attributed to oxidative stress. This is due to a collapse in the balance between free radicals in the body and the antioxidant defense system in the body, and it can be exacerbated during exercise, in obesity or people with diabetes or mextabolic syndrome. The purpose of this study was to investigate the effect of short-term colostrum use on malondialdehyde index and total antioxidant capacity in response to a session of aerobic exhaustion in female futsal student students. Methodology In a semi-experimental study, a total of 18 female futsal students were randomly divided into two groups of placebo therapy and supplementation. The people in the supplement group used 2 capsules of colostrum daily for two weeks and the other group received placebo therapy (dextrose capsule). The two groups after 2 weeks use of colostrum supplement start their activities on an aerobic exhaust test on a treadmill. Blood samples were collected in 4 stages: 1) before colostrum supplementation; 2) colostrum supplementation after 2 weeks; 3) immediately after exercise exertion 4) 24 hours after exercise. Then, two indicators malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured. Data were analyzed by Analysis of variance with repeated measures. Before than the variance analysis be done, First, the normal distribution test was performed using a Makhly test, which is also known as spherical test. Findings The results indicated that MDA increased in the steps of immediately and 24 hours after activity in both groups of placebo therapy and supplementation. That this increase was more significant in placebo therapy group (p = 0.001). Also, the antioxidant capacity increased further after supplementation in the supplement group compared to the placebo group (p≤0.05). Conclusion In general, one can say that the short-term supplementation of the colostrum inhibits the oxidative stress induced by the exhausting aerobic activity by reducing MDA and increasing the antioxidant-titin capacity in female futsalist students.