Abstarct: Background and Objectives: Sensory-motor nerves function is impaired in peripheral neuropathy which may consequently attenuate proprioception motion perception. They finally lead to impaired walking pattern and balance resulting in the risk of falling and related injuruies. The present study aimed to investigte the effect of resistance training on balance, walking, reaction time and center of foot pressure in patients with type 2 diabetes and peripheral neuropathy. Materials and Methods: In a randomized clinical trial, 30 women with type 2 diabetes and diagnosed with peripheral neuropathy using MDNS score and nerve conduction studies, were randomly assigned into experimental (53.10±4.1 yrs, 86.7±9.08 kg) and control (52.2±9.5 yrs, 88.5±8.6 kg) groups. Before and 48h following the experimental period, body composition measurements, blood sampling (in fasting state and 2h postprandial) and functional analysis were performed. Training regimen consisted of resistance training with 50 of one-maximum repetition, 10-20 repetitions, 1-2 sets with the frequency of 3 -sessions per week over 12 weeks. The data were analyzed using the statistical tests of Shapiro-Wilk, paired and independent t-test and repeated measure analysis of variance at significance level of P<0.05. Results: Data analysis showed that fasting glucose, 2hpp and HbA1C levels significantly decreased in the experimental group (P<0.05). Moreover, other variables including balance and walking index significantly increased (P<0.05) and falling index and reaction time decreased in the experimental group compared to control condition (P<0.05). However, COP did not change significantlt at both conditions (P>0.05). Conclusion: baxsed on the results of the present study, it could be concluded that 12-week resistance training could have favorable effect on glucose control and balance, walking and reaction time in patients with type 2 diabetes and peripheral neuropathy. This may be due to improved strength and neuromuscular coordination in the lower exterimity. However, according to COP data, our protocol might have no remarkable effect on proprioception in this population. baxsed on the short length of the intervention in this study and paucity of research in this regard, it needs to be further explored in future studies.