Abstarct: Purpose: the purpose of the present study was to investigate the effect of HIIT along with chromium picolinate supplementation on glycemic control and insulin resistance in type 2 diabetes women. Materials and methods: This study was a clinical trial and included pre-test and post- test . the sample of this study were type 2 diabetes women (mean ± sd: age: 53.15±6.25yr , BMI: 30.05± 4.16 kg.m^2) that randomly assigned to one of the following groups : exercise group, exercise+ supplement group, supplement group and control group. Both Supplement group and exercise+ supplement group, daily ingested 200 µgr chromium supplement in the form of a tablet. at the beginning of study and 48h after the last session of exercise and supplement ingestion, fast blood sampling and body composition was measured. The time assigned for HIIT was 45 min that included: 10 min warm up at 50%-70% HRR and 4 bouts (the duration of each bout was 4 min) of jogging or running at 85- 95% HRR on the treadmill. All data were analyzed using the statistical software SPSS version 23 (IBM). the normality of all data was tested by the Shapiro-Wilk test .one way ( ANOVA) analysis of variance was performed to identify between group variations and post hoc analysis was performed using Tukey post hoc test. The level of significant was set at p<o.o5. Results The analysis of data showed that there isn’t significant decrease in glucose, , LDL, HDL, insulin resistance, WHR, BMI and body fat percentage(p≥0.05).serum insulin level significantly decreased in supplement and supplement+ exercise group (p= 0.001).also Hb A1c significantly decreased in exercise and supplement+ exercise (p=0.015) Conclusion baxsed on the results from present study it seems that HIIT and ingestion of chromium can have positive effects on glucose control and other indicators related to diabetes in type 2 diabetes patients.