Abstarct: Objective: In the last few decades increased prevalence of type 2 diabetes in developing countries, made efforts to reduce the complications of type 2 diabetes. Physical activity and exercise have been considered over the decades as one of the pillars of diabetes care and management, with the small cost and non-pharmacological nature of physical activity increasing its therapeutic value. Several factors and hormones have been identified, including fgf21, that have been lixnked to the mextabolic action of the body, and over the past few years, this hormone has been studied as a cure for diabetes. The aim of this study was to investigate the effect of 8 weeks of Endurance and resistance training on fibroblast growth factor 21 (FGF21) in type 2 diabetic wome. Methods: this quasi-experimental study included a pre-test and post-test. Participants of the study were type II diabetic women with with a range of 40-60 years old who were divided into three groups: endurance, resistance and control. The endurance group performed aerobic exercises in the first 4 weeks for 20-30 minutes and at 50% heart rate, and In the fifth to eighth weeks, they performed 60% heart rate for 35-30 minutes. The resistance group performed exercises using gym equipment at the first and second weeks in two sets and from the third week to the end of the course in three sets with a strength of 75% 1RM. Dependent t-test to evaluate differences within a group, analysis of covariance to assess the difference between the group and the Bonferroni post hoc test to identify the groups that make a difference in the analysis of covariance had given a significant level of p≤0.05 was used. Results: In comparison between groups the fgf21 of the endurance group (p = 0.03) had a significant decrease compared to the control group. Also, glucose decreased significantly in the endurance group (p = 0.04) after the intervention. Conclusion: According to the results of this study, aerobic training seems to have a greater effect on resistance to fibroblast growth factor 21 than resistance training and also decreases the risk factors in women with type 2 diabetes.