Abstarct: Ultrasonic waves are an advanced oxidation process that can have a significant effect on flotation efficiency by changing the nature of the pulp surface and the surface of mineral particles. Hence, in this research, the influence of ultrasonic was investigated on flotation efficiency of Bama carbonate soil sample. In this regard, response surface methodology was used to design the experiments and to investigate the behavior of effective important parameters such as ultrasonic frequency, time and power and consumption value of reagents including collector, sodium sulfide and frother. The results indicated that parameters had a similar behavior at both frequency of 37 and 80 kHz and the value of recovery increased with increasing ultrasonic time and power. Also, the increase of the dose of collector, frother and sodium sulfide up to a certain value had the positive effect on the improvement of recovery. In addition, among parameters, the consumption of frother, ultrasonic time and the interactive effect of ultrasonic power with the amount of collector had the greatest influence on lead flotation recovery. Optimization of lead ultrasonic flotation was performed and the maximum efficiency rate (about 92%) was obtained under desirable conditions of parameters including ultrasonic time of 17 minutes, ultrasonic device power of 80% (1 kW), collector dose of 259 g/ton, sodium sulfide dose of 3867 g/ton, frother dose of 11 g/ton and frequency of 37 kHz.