Abstarct: In this thesis, after introducing type 1 diabetes mellitus and its mathematical models, Bergman's model is used for designing a controller. First, a second-order sliding mode controller with supertwisting algorithm is designed to regulate the blood glucose level in diabetic patient. Afterwards, an adaptive backstepping sliding mode controller is designed and presented as the main method of this study. The stability of the closed loop system is also studied baxsed on the theory of Lyapunov. Simulation results show the faster performance of adaptive backstepping sliding mode controller in reducing the patient's blood glucose by determining the acceptable dose of insulin.