Abstarct: Nowadays, nanoparticles have attracted much attention due to their unique characteristic as the result of comprising small size and high surface area. Among various applications, applying nanoparticles in catalysis and drug delivery process has attracted more attention in this study. In one hand, catalytic property of alkene epoxidation has been detected using two different heterogeneous catalysis. The first system was synthesized baxsed on a molybdenum complex supported on amine-functionalized natural sepiolite–type clay mineral as a recyclable inorganic-organic hybrid catalyst. The second catalytic system was baxsed on the preparation of novel core-shell nano magnetic MOFs via in-situ synthesis of different nano MOFs as shells over the surface of pre-synthesized amine functionalized magnetic nanoparticles. Finally, the epoxidation activity and following optimization of different effective parameters on the catalytic yield has been detected. Both systems shown high catalytic activity in epoxidation of alkenes. On the other hand, in terms of drug studies, the design and synthesis of three novel MOF nanoparticles loaded with ICG as a light-sensitive drug has been carried out to evaluate their antimicrobial activity in photodynamic therapy treatment of dental infections caused by E. fecallis bacteria in root canal. The nano carriers showed high potential in decreasing oral bacteria. Additionally Alendronate loaded ß-Cyclodextrine modified Fe besed MOF encapsulated Hydroxyapatite as a thin laxyer coating agent has been designed and synthesized as a drug carrier system to study the alendronate slow release profile. The coated nano carrier showed controlled release in slow rate in long period. The structure of all synthesized compounds was confirmed using various spectrophotometric data.