Abstarct: The Dos of Gamma ray is in fact the amount of energy that the ray transmits to the unite mass of substance when a crossing of that in some reactions that the major of them are: Photoelectric, Compton, paire production so that it Causes ionization and excitation of electrons and the Transmission of energy. The human body has different tissues and so depended on which part of the body is radiated, radiation has different effect on the adjacent tissues. This subject shows the importance of the measurement of Depth-dose and angular distribution of that in different tissues and diversity of possible statues. In this research by using of Monte Carlo simulation and MCNP-4C Code that have the power of porting of photons’ particles, electron and neutron dependently and independently, the simulation of soft tissue, Bone, fat and muscle have been done. Details of the geometry of problem, spring properties and the component of the body tissues have been defined and by using that, the amount of Depth-Dose and angular distribution of that in range of energy between .025-50 MeV have been simulated by Monte Carlo method. Then, the effect of dimension of phantom in Dose and angular distribution has been investigated in different tissues. By using of results from Monte Carlo simulation, some experiments have been done in the water phantom that was equal to the body tissues. Comparisons of Monte Carlo simulation and experimental results have a good agreement So we can use Monte Carlo simulation for calculating Dose in every tissue with every size whereas measurement of Dose by experimental method in some tissues are very hard and sometime even it’s impossible.