Abstarct: Loss of muscle mass is one of the side effects of diabetes that may be delayed by regulating blood sugar levels through exercise or herbal supplements. The 35 male rats (180±10 g) divided into 7 groups: control, diabetic, diabetic + exercise, diabetic + vanadium, diabetic + exercise + vanadium, diabetic + stevia and diabetic+ exercise + stevia. To induce type1 diabetes, streptozotocin (55mg/kg) was injected intraperitoneally, and vanadium extract (1mg/ml) was dissolved in water daily. The endurance training program consisted of eight weeks of treadmill running, five days a week, starting at 15 minutes at 20 meters/minute and ending at 35 minutes at 30 meters/minute in the final week. Histopathological changes in brain tissue were examined using a light microscope. In order to normalize the parametric data, Kolmogorov-Smirnov test and for their analysis, one-way ANOVA with Bonferroni post hoc test, and for non-parametric data, Kruskal-Wallis test (p ≤ 0.05) was used. Results: Body weight values in all six experimental groups compared to healthy control group (p=0.001), in vanadium group compared to vanadium+exercise (p = 0.01), and in stevia+exercise group compared to stevia (p = 0.04), decreased significantly. In the diabetic group, slight changes in cell number and size improved with exercise and along with vanadium and stevia, and consumption of stevia, as well as cell degeneration, with exercise and along with vanadium and stevia, and consumption of vanadium and stevia (p=0.001). Eight weeks of endurance exercise, stevia and vanadium intake appear to be effective in regulating body weight as well as improving the hamstring muscle damage caused by diabetes.